Mathematical modeling of fluid movement inside the eyeball during intravitreal injection

Intravitreal injections show an avalanche-like growth the world over. Purposes: 1) create a mathematical model of eyeball and fluid movement inside eye, assuming simplified structure vitreous body (without tanks); 2) estimate time span when drug substance remains in cavity until it is completely washed out, depending on injection site; 3) observe evaluate path cavity; 4) variation located cavity, presence or absence complete detachment body. Results. If injected closer to center eyeball, increased as compared parietal injection. With full detachment, location increases its normal location, which favorably affects prolongation therapeutic effect. Conclusion. As this pilot study, many parameters are approximate, so results obtained cannot be mechanically extrapolated live human eye subjected intravitreal injections, due complexity processes occurring eyeball.